Source: LTspice: Importing and Exporting WAV & PWL Text Files
Voltage sources can be driven by a wav files (mono). Example with a file “simple440_small.wav”
CTRL + right click on the source and change the value parameter to wavefile=simple440_small.wav
A wav file can also be saved as output using the “.wave” spice directive
If a more general waveform file is packed into a wav file, this can be used as input for a simulated circuit.
For instance, a waveform from a Silicon PhotoMultiplier can be saved to a wav file like this
and used as input for LTspice like this (a low-pass filter with a ~ 60 MHz f3dB to suppress noise)
Using the “.wave” spice directive the result can be saved and read back agina in Python